Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV.

ABSTRACT: HIV-infected women may be particularly vulnerable to verbal learning and memory deficits. One factor contributing to these deficits is high perceived stress, which is associated with prefrontal cortical (PFC) atrophy and memory outcomes sensitive to PFC function, including retrieval and semantic clustering. We examined the association between stress and PFC activation during a verbal memory task in 36 HIV-infected women from the Chicago Consortium of the Women's Interagency HIV Study (WIHS) to better understand the role of the PFC in this stress-related impairment. Participants completed standardized measures of verbal learning and memory and stress (perceived stress scale-10). We used functional magnetic resonance imaging to assess brain function while participants completed encoding and

SUBMITTER: Rubin LH 

PROVIDER: S-EPMC5071112 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature