Dissecting bipolar disorder complexity through epigenomic approach.
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ABSTRACT:
SUBMITTER: Ludwig B
PROVIDER: S-EPMC5071130 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Dissecting bipolar disorder complexity through epigenomic approach.
Molecular psychiatry 20160802 11
In recent years, numerous studies of gene regulation mechanisms have emerged in neuroscience. Epigenetic modifications, described as heritable but reversible changes, include DNA methylation, DNA hydroxymethylation, histone modifications and noncoding RNAs. The pathogenesis of psychiatric disorders, such as bipolar disorder, may be ascribed to a complex gene-environment interaction (G × E) model, linking the genome, environmental factors and epigenetic marks. Both the high complexity and the hig ...[more]
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