Molecular Epidemiology of Colonizing and Infecting Isolates of Klebsiella pneumoniae.

ABSTRACT: Klebsiella pneumoniae is among the most common causes of hospital-acquired infections and has emerged as an urgent threat to public health due to carbapenem antimicrobial resistance. K. pneumoniae commonly colonizes hospitalized patients and causes extraintestinal infections such as urinary tract infection, bloodstream infection (septicemia), and pneumonia. If colonization is an intermediate step before infection, then detection and characterization of colonizing isolates could enable strategies to prevent or empirically treat K. pneumoniae infections in hospitalized patients. However, the strength of the association between colonization and infection is unclear. To test the hypothesis that hospitalized patients become infected with their colonizing strain, 1,765 patie

SUBMITTER: Martin RM 

PROVIDER: S-EPMC5071533 | biostudies-literature | 2016 Sep-Oct

REPOSITORIES: biostudies-literature