Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat.

ABSTRACT:

Background and purpose

Essential tremor (ET) is a neurological disorder with unknown aetiology. Its symptoms include cerebellar motor disturbances, cognitive and personality changes, hearing and olfactory deficits. Hyperactivity of excitotoxic cerebellar climbing fibres may underlie essential tremor and has been induced in rodents by systemic harmaline administration. Cannabinoid (CB) receptor agonists can cause motor disturbances; although, there are also anecdotal reports of therapeutic benefits of cannabis in motor disorders. We set out to establish the effects of CB receptor agonism and antagonism on an established rodent model of ET using a battery of accepted behaviour assays in order to determine the risk and therapeutic potential of modulating the endocannabinoid system in

SUBMITTER: Abbassian H 

PROVIDER: S-EPMC5071561 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature