Role of the nicotinic acetylcholine receptor α3 subtype in vascular inflammation.

ABSTRACT:

Background and purpose

Vascular inflammation is a major factor contributing to the development of vascular diseases. The aim of this study was to investigate the role of the nicotinic acetylcholine receptor α3 subtype (α3-nAChR) in vascular inflammation.

Experimental approach

Vascular inflammation was studied in apolipoprotein E knockout (ApoE^-/- ) mice fed a high-fat diet. Inflammatory markers were measured in mouse aortic endothelial cells (MAECs) and macrophages after α3-nAChRs were antagonized pharmacologically, or after the gene of α3-nAChRs was silenced.

Key results

Treatment with α-conotoxin MII (MII; an α3-nAChR antagonist) increased the number of inflammatory cells infiltrating the aortic walls and further impaired the endothelium-dependent vasodil

SUBMITTER: Yang C 

PROVIDER: S-EPMC5071564 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature