Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes.

ABSTRACT: Self-reactive thymocytes are eliminated by negative selection, whereas competent thymocytes survive by positive selection. The strength of the T-cell receptor (TCR) signal determines the fate of thymocytes undergoing either positive or negative selection. The TCR signal strength is relatively higher in negative selection than in positive selection and induces pro-apoptotic molecules such as Nur77 and Nor-1, which are members of the orphan nuclear receptor family, that then cause TCR-mediated apoptosis. However, at the molecular level, it remains unclear how positive or negative selection is distinguished based on the TCR signal. We found that the expression of Twist2 is differentially regulated in positively and negatively selected thymocytes. In particular, TCR signal strength that elicit

SUBMITTER: Oh S 

PROVIDER: S-EPMC5071571 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature