Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages.

ABSTRACT: Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease, characterized by chronic inflammatory demyelination in the nervous tissue and subsequent neurological dysfunction. Spermidine, a natural polyamine, has been shown to affect inflammation in some experimental models. We show here that spermidine could alleviate experimental autoimmune encephalomyelitis (EAE), a model for MS, through regulating the infiltration of CD4⁺ T cells and macrophages in central nervous system. Unexpectedly, we found that spermidine treatment of MOG-specific T cells did not affect their pathogenic potency upon adaptive transfer; however, spermidine diminished the ability of macrophages in activating MOG-specific T cells ex vivo. Depletion of macrophages in diseased mice completely abo

SUBMITTER: Yang Q 

PROVIDER: S-EPMC5071574 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature