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Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata.

ABSTRACT: Two new phenylpropanoid glycosides named cuneataside E (1) and cuneataside F (2), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 ?mol/L, compound 1 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HeG2 cells.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC5071639 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Two new phenylpropanoid glycosides from the aerial parts of <i>Lespedeza cuneata</i>.

Zhang Chuangfeng C   Zhou Jian J   Yang Jingzhi J   Li Chuangjun C   Ma Jie J   Zhang Dan D   Zhang Dongming D  

Acta pharmaceutica Sinica. B 20160617 6

Two new phenylpropanoid glycosides named cuneataside E (<b>1</b>) and cuneataside F (<b>2</b>), were isolated from the aerial parts of <i>Lespedeza cuneata</i> (Dum. Cours.) G. Don, whose structures were <i>E</i> and <i>Z</i> isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In <i>in vitro</i> bioassays at 10 μmol/L, compound <b>1</b> showed moderate hepatoprotective activity against <i>N</i>-acetyl-<i>  ...[more]

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