A new paradigm for producing astaxanthin from the unicellular green alga Haematococcus pluvialis.

ABSTRACT: The unicellular green alga Haematococcus pluvialis has been exploited as a cell factory to produce the high-value antioxidant astaxanthin for over two decades, due to its superior ability to synthesize astaxanthin under adverse culture conditions. However, slow vegetative growth under favorable culture conditions and cell deterioration or death under stress conditions (e.g., high light, nitrogen starvation) has limited the astaxanthin production. In this study, a new paradigm that integrated heterotrophic cultivation, acclimation of heterotrophically grown cells to specific light/nutrient regimes, followed by induction of astaxanthin accumulation under photoautotrophic conditions was developed. First, the environmental conditions such as pH, carbon source, nitrogen regime, and light intens

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC5071682 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature