Screening of Two ADH4 Variations in a Swedish Cluster Headache Case-Control Material.

ABSTRACT:

Background

Cluster headache (CH) is a severe neurovascular disorder and an increasing amount of evidence points to a genetic contribution to this disease. When CH was first described, it was observed that alcohol may precipitate an attack during the active phase of the disease. The alcohol dehydrogenase 4 (ADH4) gene encodes an enzyme which contributes to the metabolization of alcohol and is, therefore, an interesting candidate gene for CH. Two Italian groups have reported association of the single nucleotide polymorphism (SNP) rs1126671 located in the ADH4 gene with an increased risk of CH in Italy. In addition, one of the groups found an association between the ADH4 SNP rs1800759 and CH.

Objective

To perform a replication study on the ADH4 SNPs rs1126671 and rs1800759 in a

SUBMITTER: Fourier C 

PROVIDER: S-EPMC5071723 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature