Intratumoral heterogeneity: Role of differentiation in a potentially lethal phenotype of testicular cancer.

ABSTRACT:

Background

Intratumoral heterogeneity presents a major obstacle to the widespread implementation of precision medicine. The authors assessed the origin of intratumoral heterogeneity in nonseminomatous germ cell tumor of the testis (NSGCT) and identified distinct tumor subtypes and a potentially lethal phenotype.

Methods

In this retrospective study, all consecutive patients who had been diagnosed with an NSGCT between January 2000 and December 2010 were evaluated. The histologic makeup of primary tumors and the clinical course of disease were determined for each patient. A Fine and Gray proportional hazards regression analysis was used to determine the prognostic risk factors, and the Gray test was used to detect differences in the cumulative incidence of cancer death. In a s

SUBMITTER: Tu SM 

PROVIDER: S-EPMC5071733 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature