Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification.

ABSTRACT: In brains of Alzheimer's disease (AD), reactive oxygen species (ROS) levels are significantly higher than that of healthy brains. Evidence suggests that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Aβ) production, aggregation, plaque formation, microglia/immunological responses, inflammation, and ROS production. In this cycle, ROS species play a central role, and H₂O₂ is one of the most important ROS species. In this report, we have designed a fluorescent imaging probe CRANAD-88, which is capable of cascade amplifying near infrared fluorescence (NIRF) signals at three levels upon interacting with H₂O₂ in AD brains. We demonstrated that the amplification was feasible in vitro and in vivo. Remarkably, we showed th

SUBMITTER: Yang J 

PROVIDER: S-EPMC5071891 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature