Molecular characterization of host-parasite cell signalling in Schistosoma mansoni during early development.

ABSTRACT: During infection of their human definitive host, schistosomes transform rapidly from free-swimming infective cercariae in freshwater to endoparasitic schistosomules. The 'somules' next migrate within the skin to access the vasculature and are surrounded by host molecules that might activate intracellular pathways that influence somule survival, development and/or behaviour. However, such 'transactivation' by host factors in schistosomes is not well defined. In the present study, we have characterized and functionally localized the dynamics of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK) activation during early somule development in vitro and demonstrate activation of these protein kinases by human epidermal growth factor, insulin, and insulin-like growth factor I,

SUBMITTER: Ressurreicao M 

PROVIDER: S-EPMC5071895 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature