Study to explore the mechanism to form inclusion complexes of β-cyclodextrin with vitamin molecules.

ABSTRACT: Host-guest inclusion complexes of β-cyclodextrin with two vitamins viz., nicotinic acid and ascorbic acid in aqueous medium have been explored by reliable spectroscopic, physicochemical and calorimetric methods as stabilizer, carrier and regulatory releaser of the guest molecules. Job's plots have been drawn by UV-visible spectroscopy to confirm the 1:1 stoichiometry of the host-guest assembly. Stereo-chemical nature of the inclusion complexes has been explained by 2D NMR spectroscopy. Surface tension and conductivity studies further support the inclusion process. Association constants for the vitamin-β-CD inclusion complexes have been calculated by UV-visible spectroscopy using both Benesi-Hildebrand method and non-linear programme, while the thermodynamic parameters have been estimated w

SUBMITTER: Saha S 

PROVIDER: S-EPMC5071908 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature