High-Resolution Mapping of Postinfarction Reentrant Ventricular Tachycardia: Electrophysiological Characterization of the Circuit.

ABSTRACT:

Background

In vivo description of ventricular tachycardia (VT) circuits is limited by insufficient spatiotemporal resolution. We used a novel high-resolution mapping technology to characterize the electrophysiological properties of the postinfarction reentrant VT circuit.

Methods

In 15 swine, myocardial infarction was induced by left anterior descending artery balloon occlusion. Animals were studied 6 to 8 weeks after myocardial infarction. Activation mapping of VTs was performed by using the Rhythmia mapping system. Activation time was based on a combination of bipolar and unipolar electrograms. The response to overdrive pacing from different zones of the circuit was examined.

Results

A total of 56 monomorphic VTs were induced (3.8±2.1 per animal). Among these, 21 (3

SUBMITTER: Anter E 

PROVIDER: S-EPMC5072375 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature