Ontology highlight
ABSTRACT:
SUBMITTER: Hornsveld M
PROVIDER: S-EPMC5072425 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Cell death and differentiation 20160401 9
Loss of cellular adhesion leads to the progression of breast cancer through acquisition of anchorage independence, also known as resistance to anoikis. Although inactivation of E-cadherin is essential for acquisition of anoikis resistance, it has remained unclear how metastatic breast cancer cells counterbalance the induction of apoptosis without E-cadherin-dependent cellular adhesion. We report here that E-cadherin inactivation in breast cancer cells induces PI3K/AKT-dependent FOXO3 inhibition ...[more]