PPARG-LYPLAL1 Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females.

ABSTRACT:

Objective

We studied multi-loci variants to identify the contribution of six candidate genes (ADIPOQ, CDH13, LYPLAL1, MC4R, PPARG and PGC1A) in the development of obesity and overweight.

Design

We genotyped 404 chromosomes with eleven SNPs in Mexican female adolescents, who were subdivided into two groups (obesity-overweight and normal-weight) using the World Health Organization parameters. Genomic (800 chromosomes) and ancestral (208 chromosomes) controls were included to reduce the population bias. Anthropometric measurements, biochemical parameters, and caloric intake were obtained only in the groups of Mexican female adolescents.

Results

A positive genotype-phenotype association was found that involves the multi-allelic combination of three risk alle

SUBMITTER: Hernandez-Tobias EA 

PROVIDER: S-EPMC5072476 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature