Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.

ABSTRACT: Redirecting T cells to attack cancer using engineered chimeric receptors provides powerful new therapeutic capabilities. However, the effectiveness of therapeutic T cells is constrained by the endogenous T cell response: certain facets of natural response programs can be toxic, whereas other responses, such as the ability to overcome tumor immunosuppression, are absent. Thus, the efficacy and safety of therapeutic cells could be improved if we could custom sculpt immune cell responses. Synthetic Notch (synNotch) receptors induce transcriptional activation in response to recognition of user-specified antigens. We show that synNotch receptors can be used to sculpt custom response programs in primary T cells: they can drive a la carte cytokine secretion profiles, biased T cell differentiation

SUBMITTER: Roybal KT 

PROVIDER: S-EPMC5072533 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature