Longitudinal Analysis of Patient Specific Predictors for Mortality in Sickle Cell Disease.

ABSTRACT:

Introduction

White Blood Cell (WBC) count, %HbF, and serum creatinine (Cr), have been identified as markers for increased mortality in sickle cell anemia (SCA) but no studies have examined the significance of longitudinal rate of change in these or other biomarkers for SCA individuals.

Methods

Clinical, demographic and laboratory data from SCA patients seen in 2002 by our hospital system were obtained. Those who were still followed in 2012 (survival cohort) were compared to those who had died in the interim (mortality cohort). Patients lost to follow-up were excluded. Age adjusted multivariable Cox proportional hazards models were constructed to assess hazard ratios of mortality risk associated with the direction and degree of change for each variable.

Results

359 SCA

SUBMITTER: Curtis SA 

PROVIDER: S-EPMC5072581 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature