Model Based Analysis of Clonal Developments Allows for Early Detection of Monoclonal Conversion and Leukemia.

ABSTRACT: The availability of several methods to unambiguously mark individual cells has strongly fostered the understanding of clonal developments in hematopoiesis and other stem cell driven regenerative tissues. While cellular barcoding is the method of choice for experimental studies, patients that underwent gene therapy carry a unique insertional mark within the transplanted cells originating from the integration of the retroviral vector. Close monitoring of such patients allows accessing their clonal dynamics, however, the early detection of events that predict monoclonal conversion and potentially the onset of leukemia are beneficial for treatment. We developed a simple mathematical model of a self-stabilizing hematopoietic stem cell population to generate a wide range of possible clonal devel

SUBMITTER: Baldow C 

PROVIDER: S-EPMC5072636 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature