IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering.

ABSTRACT: Analysis of gene sets has been widely applied in various high-throughput biological studies. One weakness in the traditional methods is that they neglect the heterogeneity of genes expressions in samples which may lead to the omission of some specific and important gene sets. It is also difficult for them to reflect the severities of disease and provide expression profiles of gene sets for individuals. We developed an application software called IGSA that leverages a powerful analytical capacity in gene sets enrichment and samples clustering. IGSA calculates gene sets expression scores for each sample and takes an accumulating clustering strategy to let the samples gather into the set according to the progress of disease from mild to severe. We focus on gastric, pancreatic and ovarian canc

SUBMITTER: Wu L 

PROVIDER: S-EPMC5072653 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature