Ccoffinn: Automated Wave Tracking in Cultured Cardiac Monolayers.

ABSTRACT: Cardiac arrhythmias are one of the most frequent causes of death worldwide. A popular biological model used to study arrhythmogenesis is the cultured cardiac cell monolayer, which provides a good trade-off between physiological relevance and experimental access. Excitation wave patterns are imaged using high-bandwidth detectors, producing large data sets that are typically analyzed manually. To make such analysis less time consuming and less subjective, we have designed and implemented a toolkit for segmentation and tracking of cardiac waves in optical mapping recordings. The toolkit is optimized for high-resolution detectors to accommodate the growing availability of inexpensive high-resolution detectors for life science imaging applications (e.g., scientific CMOS cameras). The software e

SUBMITTER: Tomek J 

PROVIDER: S-EPMC5072981 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature