Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice.

ABSTRACT:

Background

Alcohol use disorders are associated with single-nucleotide polymorphisms in GABRA2, the gene encoding the GABA_A receptor α2-subunit in humans. Deficient GABAergic functioning is linked to impulse control disorders, intermittent explosive disorder, and to drug abuse and dependence, yet it remains unclear whether α2-containing GABA_A receptor sensitivity to endogenous ligands is involved in excessive alcohol drinking.

Methods

Male wild-type (Wt) C57BL/6J and point-mutated mice rendered insensitive to GABAergic modulation by benzodiazepines (BZD; H101R), allopregnanolone (ALLO) or tetrahydrodeoxycorticosterone (THDOC; Q241M), or high concentrations of ethanol (EtOH) (S270H/L277A) at α2-containing GABA_A receptors were assessed for thei

SUBMITTER: Newman EL 

PROVIDER: S-EPMC5073020 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature