Microglial phenotypes in Parkinson's disease and animal models of the disease.

ABSTRACT: Over the last decade the important concept has emerged that microglia, similar to other tissue macrophages, assume different phenotypes and serve several effector functions, generating the theory that activated microglia can be organized by their pro-inflammatory or anti-inflammatory and repairing functions. Importantly, microglia exist in a heterogenous population and their phenotypes are not permanently polarized into two categories; they exist along a continuum where they acquire different profiles based on their local environment. In Parkinson's disease (PD), neuroinflammation and microglia activation are considered neuropathological hallmarks, however their precise role in relation to disease progression is not clear, yet represent a critical challenge in the search of disease-modifyi

SUBMITTER: Joers V 

PROVIDER: S-EPMC5073045 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature