Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood.

ABSTRACT: Development of the intestinal microbiota during early life serves as a key regulatory stage in establishing the host-microbial relationship. This symbiotic relationship contributes to developing host immunity and maintaining health throughout the life span. This study was to develop an approach to colonize conventionally raised mice with a model probiotic bacterium, Lactobacillus rhamnosus GG (LGG), and to determine the effects of LGG colonization on intestinal development and prevention of colitis in adulthood. LGG colonization in conventionally raised was established by administering LGG to pregnant mice starting at gestational day 18 and pups at postnatal days 1- 5. LGG colonization promoted bodyweight gain and increased diversity and richness of the colonic mucosa-associated microbiota

SUBMITTER: Yan F 

PROVIDER: S-EPMC5073052 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature