The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.

ABSTRACT: A primary cilium is present on most eukaryotic cells and represents a specialized organelle dedicated to signal transduction and mechanosensing. Defects in cilia function are the cause for several human diseases called ciliopathies. The serologically defined colon cancer antigen-3 (SDCCAG3) is a recently described novel endosomal protein mainly localized at early and recycling endosomes and interacting with several components of membrane trafficking pathways. Here we describe localization of SDCCAG3 to the basal body of primary cilia. Furthermore, we demonstrate that decreased expression levels of SDCCAG3 correlate with decreased ciliary length and a reduced percentage of ciliated cells. We show that SDCCAG3 interacts with the intraflagellar transport protein 88 (IFT88), a crucial componen

SUBMITTER: Yu F 

PROVIDER: S-EPMC5073310 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature