A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis.

ABSTRACT: Gastrointestinal symptoms are common in children with autism spectrum disorder (ASD). A significant proportion of children with ASD and gastrointestinal symptoms have histologic evidence of ileocolitis (inflammation of the terminal ileum and/or colon). We previously reported the molecular characterization of gastrointestinal biopsy tissue from ASD children with ileocolitis (ASD^IC+) compared to anatomically similar inflamed tissue from typically developing children with inflammatory bowel disease (IBD; i.e. Crohn's disease or ulcerative colitis) and typically developing children with gastrointestinal symptoms but no evidence of gastrointestinal mucosal inflammation (TD^IC-). ASD^IC+ children had a gene expression profile that, while primarily overlapping with

SUBMITTER: Walker SJ 

PROVIDER: S-EPMC5073317 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature