The 2014 Ebola virus outbreak in West Africa highlights no evidence of rapid evolution or adaptation to humans.

ABSTRACT: Following its immergence in December 2013, the recent Zaire Ebola virus (EBOV) outbreak in West Africa has spread and persisted for more than two years, making it the largest EBOV epidemic in both scale and geographical region to date. In this study, a total of 726 glycoprotein (GP) gene sequences of the EBOV full-length genome obtained from West Africa from the 2014 outbreak, combined with 30 from earlier outbreaks between 1976 and 2008 were used to investigate the genetic divergence, evolutionary history, population dynamics, and selection pressure of EBOV among distinct epidemic waves. Results from our dataset showed that no non-synonymous substitutions occurred on the GP gene coding sequences of EBOV that were likely to have affected protein structure or function in any way. Furthermor

SUBMITTER: Li X 

PROVIDER: S-EPMC5073338 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature