Genetic diversity of the merozoite surface protein-3 gene in Plasmodium falciparum populations in Thailand.

ABSTRACT:

Background

An effective malaria vaccine is an urgently needed tool to fight against human malaria, the most deadly parasitic disease of humans. One promising candidate is the merozoite surface protein-3 (MSP-3) of Plasmodium falciparum. This antigenic protein, encoded by the merozoite surface protein (msp-3) gene, is polymorphic and classified according to size into the two allelic types of K1 and 3D7. A recent study revealed that both the K1 and 3D7 alleles co-circulated within P. falciparum populations in Thailand, but the extent of the sequence diversity and variation within each allelic type remains largely unknown.

Methods

The msp-3 gene was sequenced from 59 P. falciparum samples collected from five endemic areas (Mae Hong Son, Kanchanaburi, Ranong, Trat and Ubon Ratch

SUBMITTER: Pattaradilokrat S 

PROVIDER: S-EPMC5073822 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature