Four-helix bundle: a ubiquitous sensory module in prokaryotic signal transduction.

ABSTRACT:

Motivation

Transmembrane chemoreceptors in Escherichia coli utilize ligand-binding domains for detecting various external signals. The structure of this domain in the E.coli aspartate receptor, Tar, is known and its signal transduction mechanism is under investigation. Current domain models for this important sensory module are inaccurate and, therefore, cannot reveal the distribution of this domain within the current genomic landscape.

Results

We carried out sensitive and exhaustive PSI-BLAST searches initiated with the sequence corresponding to a known structure of the four-helix, ligand-binding domain of the aspartate chemoreceptor. From the resulting sequences, we built a multiple sequence alignment for this domain family, which confirmed that the current TarH model is e

SUBMITTER: Ulrich LE 

PROVIDER: S-EPMC5073874 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature