Identification of internalin-A-like virulent proteins in Leishmania donovani.

ABSTRACT:

Background

An active immune surveillance and a range of barriers to infection allow the host to effectively eliminate microbial pathogens. However, pathogens may use diverse strategies to subdue such host defences. For instance, one such mechanism is the use of leucine-rich repeat (LRR) proteins by pathogens (microbial) to cause infection. In this study, we aimed at identifying novel virulence factor(s) in Leishmania donovani, based on the possibility of lateral gene transfers of bacterial virulence factor(s) to L. donovani.

Methods

Rigorous homology searching protocols including Hidden Markov Model (HMM) and BLASTp based searches were employed to detect remote but significant similarities between L. donovani proteins and bacterial virulence factors.

Results

We found

SUBMITTER: Mukherjee I 

PROVIDER: S-EPMC5073978 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature