Dissecting the biological relationship between TCGA miRNA and mRNA sequencing data using MMiRNA-Viewer.

ABSTRACT:

Background

MicroRNAs (miRNA) are short nucleotides that interact with their target genes through 3' untranslated regions (UTRs). The Cancer Genome Atlas (TCGA) harbors an increasing amount of cancer genome data for both tumor and normal samples. However, there are few visualization tools focusing on concurrently displaying important relationships and attributes between miRNAs and mRNAs of both cancer tumor and normal samples. Moreover, a deep investigation of miRNA-mRNA target and biological relationships across multiple cancer types by integrating web-based analysis has not been thoroughly conducted.

Results

We developed an interactive visualization tool called MMiRNA-Viewer that can concurrently present the co-relationships of expression between miRNA-mRNA pairs of both tu

SUBMITTER: Bai Y 

PROVIDER: S-EPMC5073992 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature