Hypomethylation of Interleukin-6 Promoter is Associated with the Risk of Coronary Heart Disease.

ABSTRACT:

Background

Interleukin-6 (IL-6) is implicated in the pathogenesis of coronary heart disease (CHD), and IL-6 expression has associated with reduced DNA methylation of its gene promoter. However, there are no data on IL-6 promoter methylation and the risk of CHD.

Objective

To examine whether IL-6 promoter methylation measured in blood leukocyte DNA is associated with CHD risk.

Methods

A total of 212 cases with CHD and 218 controls were enrolled. Methylation at two CpG sites in IL-6 promoter was measured by bisulfite pyrosequencing, and the mean IL-6 methylation was calculated by averaging the methylation measures of the two CpGs.

Results

Mean methylation level in IL-6 promoter in CHD cases was significantly lower than that in controls (p = 0.023). Logistic regres

SUBMITTER: Zuo HP 

PROVIDER: S-EPMC5074066 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature