Chewing-induced hypertension in afferent baroreflex failure: a sympathetic response?

ABSTRACT:

New findings

What is the central question of this study? Our goal was to understand the autonomic responses to eating in patients with congenital afferent baroreflex failure, by documenting changes in blood pressure and heart rate with chewing, swallowing and stomach distension. What is the main finding and its importance? Patients born with lesions in the afferent baroreceptor pathways have an exaggerated pressor response to food intake. This appears to be a sympathetically mediated response, triggered by chewing, that occurs independently of swallowing or distension of the stomach. The chewing-induced pressor response may be useful as a counter-manoeuvre to prevent orthostatic hypotension in these patients. Familial dysautonomia (FD) is a rare genetic disease with extremely labil

SUBMITTER: Fuente Mora C 

PROVIDER: S-EPMC5074388 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature