Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.

ABSTRACT: Memory formation is a highly complex and dynamic process. It consists of different phases, which depend on various neuronal and molecular mechanisms. In adult Drosophila it was shown that memory formation after aversive Pavlovian conditioning includes-besides other forms-a labile short-term component that consolidates within hours to a longer-lasting memory. Accordingly, memory formation requires the timely controlled action of different neuronal circuits, neurotransmitters, neuromodulators and molecules that were initially identified by classical forward genetic approaches. Compared to adult Drosophila, memory formation was only sporadically analyzed at its larval stage. Here we deconstruct the larval mnemonic organization after aversive olfactory conditioning. We show that after odor-hig

SUBMITTER: Widmann A 

PROVIDER: S-EPMC5074598 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature