Continued evolution of highly pathogenic avian influenza A (H5N1): updated nomenclature.

ABSTRACT:

Background

Continued evolution of highly pathogenic avian influenza A (H5N1) throughout many regions of the eastern hemisphere has led to the emergence of new phylogenetic groups. A total of 1637 new H5N1 hemagglutinin (HA) sequences have become available since the previous nomenclature recommendations described in 2009 by the WHO/OIE/FAO H5N1 Evolution Working Group. A comprehensive analysis including all the new data is needed to update HA clade nomenclature.

Methods

Phylogenetic trees were constructed from data sets of all available H5N1 HA sequences. New clades were designated on the basis of phylogeny and p-distance using the pre-established nomenclature system (Emerg Infec Dis 2008; 14:e1). Each circulating H5N1 clade was subjected to further phylogenetic analysis and

SUBMITTER: WHO/OIE/FAO H5N1 Evolution Working Group 

PROVIDER: S-EPMC5074649 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature