SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.

ABSTRACT: Multidetector row computed tomography (MDCT) is increasingly taking a central role in identifying subphenotypes within chronic obstructive pulmonary disease (COPD), asthma, and other lung-related disease populations, allowing for the quantification of the amount and distribution of altered parenchyma along with the characterization of airway and vascular anatomy. The embedding of quantitative CT (QCT) into a multicenter trial with a variety of scanner makes and models along with the variety of pressures within a clinical radiology setting has proven challenging, especially in the context of a longitudinal study. SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study), sponsored by the National Institutes of Health, has established a QCT lung assessment system (QCT-LAS),

SUBMITTER: Sieren JP 

PROVIDER: S-EPMC5074650 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature