The roles of architecture and estrogen depletion in microdamage risk in trabecular bone.

ABSTRACT: Bone quantity, or density, has insufficient power to discriminate fracture risk in individuals. Additional measures of bone quality, such as microarchitectural characteristics and bone tissue properties, including the presence of damage, may improve the diagnosis of fracture risk. Microdamage and microarchitecture are two aspects of trabecular bone quality that are interdependent, with several microarchitectural changes strongly correlated to damage risk after compensating for bone density. This study aimed to delineate the effects of microarchitecture and estrogen depletion on microdamage susceptibility in trabecular bone using an ovariectomized sheep model to mimic post-menopausal osteoporosis. The propensity for microdamage formation in trabecular bone of the distal femur was studied us

SUBMITTER: Kreipke TC 

PROVIDER: S-EPMC5074893 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature