Griffithsin-Modified Electrospun Fibers as a Delivery Scaffold To Prevent HIV Infection.

ABSTRACT: Despite current prophylactic strategies, sexually transmitted infections (STIs) remain significant contributors to global health challenges, spurring the development of new multipurpose delivery technologies to protect individuals from and treat virus infections. However, there are few methods currently available to prevent and no method to date that cures human immunodeficiency virus (HIV) infection or combinations of STIs. While current oral and topical preexposure prophylaxes have protected against HIV infection, they have primarily relied on antiretrovirals (ARVs) to inhibit infection. Yet continued challenges with ARVs include user adherence to daily treatment regimens and the potential toxicity and antiviral resistance associated with chronic use. The integration of new biological ag

SUBMITTER: Grooms TN 

PROVIDER: S-EPMC5075055 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature