Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients.

ABSTRACT:

Background

The transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2; previously known as NRF2) is a crucial regulator of the intracellular antioxidant response. It controls the expression of genes involved in the detoxification and elimination of reactive oxidants and electrophilic agents. The role of NFE2L2 in cancer is subject of controversial discussion, as it has been reported to have both pro-and anti-tumourigenic functions. To shed some light on this paradox, we analysed the NFE2L2 mRNA expression levels in breast cancer and its association with clinicopathological features and survival.

Methods

We retrospectively evaluated the NFE2L2 mRNA expression levels in tumour tissue of two independent breast cancer patient cohorts. In the training set we ana

SUBMITTER: Wolf B 

PROVIDER: S-EPMC5075160 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature