High resting metabolic rate among Amazonian forager-horticulturalists experiencing high pathogen burden.

ABSTRACT:

Objectives

Resting metabolic rate (RMR) reflects energetic costs of homeostasis and accounts for 60 to 75% of total energy expenditure (TEE). Lean mass and physical activity account for much RMR variability, but the impact of prolonged immune activation from infection on human RMR is unclear in naturalistic settings. We evaluate the effects of infection on mass-corrected RMR among Bolivian forager-horticulturalists, and assess whether RMR declines more slowly with age than in hygienic sedentary populations, as might be expected if older adults experience high pathogen burden.

Materials and methods

RMR was measured by indirect calorimetry (Fitmate MED, Cosmed) in 1,300 adults aged 20 to 90 and TEE was measured using doubly labeled water (n = 40). Immune biomarkers, clinical d

SUBMITTER: Gurven MD 

PROVIDER: S-EPMC5075257 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature