Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.

ABSTRACT:

Background

Peripheral nerve injury is a frequent cause of lasting motor deficits and chronic pain. Although peripheral nerves are capable of regrowth they often fail to re-innervate target tissues.

Results

Using newly generated transgenic mice with inducible neuronal progranulin overexpression we show that progranulin accelerates axonal regrowth, restoration of neuromuscular synapses and recovery of sensory and motor functions after injury of the sciatic nerve. Oppositely, progranulin deficient mice have long-lasting deficits in motor function tests after nerve injury due to enhanced losses of motor neurons and stronger microglia activation in the ventral horn of the spinal cord. Deep proteome and gene ontology (GO) enrichment analysis revealed that the proteins upregulated

SUBMITTER: Altmann C 

PROVIDER: S-EPMC5075406 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature