Dataset Information

Malignant Mesothelioma Effusions Are Infiltrated by CD3⁺ T Cells Highly Expressing PD-L1 and the PD-L1⁺ Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti-PD-L1 Antibody Avelumab.

ABSTRACT:

Introduction

The functional aspects of programmed death 1 (PD-1) and PD ligand 1 (PD-L1) immune checkpoints in malignant mesothelioma have not been studied.

Methods

Tumor samples from 65 patients with mesothelioma were evaluated for PD-L1 expression by immunohistochemistry, and its prognostic significance was examined. Malignant effusions from patients with pleural and peritoneal mesothelioma were evaluated for PD-1-positive and PD-L1-positive infiltrating lymphocytes and their role in inducing PD-L1 expression in tumor cells. Antibody-dependent cellular cytotoxicity (ADCC) of avelumab, a fully humanized immunoglobulin G1 anti PD-L1 antibody against primary mesothelioma cell lines, was evaluated in presence of autologous and allogeneic natural killer cells.

Results

SUBMITTER: Khanna S

PROVIDER: S-EPMC5075512 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Malignant Mesothelioma Effusions Are Infiltrated by CD3⁺ T Cells Highly Expressing PD-L1 and the PD-L1⁺ Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti-PD-L1 Antibody Avelumab.

Introduction

Methods

Results

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Malignant Mesothelioma Effusions Are Infiltrated by CD3+ T Cells Highly Expressing PD-L1 and the PD-L1+ Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti-PD-L1 Antibody Avelumab.

Introduction

Methods

Results

OmicsDI is part of the ELIXIR infrastructure

Tweets

Malignant Mesothelioma Effusions Are Infiltrated by CD3⁺ T Cells Highly Expressing PD-L1 and the PD-L1⁺ Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti-PD-L1 Antibody Avelumab.