Discriminatory value of alanine aminotransferase for diabetes prediction: the Insulin Resistance Atherosclerosis Study.

ABSTRACT:

Aims

To examine the incremental usefulness of adding alanine aminotransferase to established risk factors for predicting future diabetes.

Methods

The study population of the Insulin Resistance Atherosclerosis Study included 724 people aged 40-69 years. We excluded people who had excessive alcohol intake or were treated with lipid-lowering agents. Incident diabetes was assessed after a mean follow-up period of 5.2 years.

Results

Alanine aminotransferase had a non-linear relationship with incident diabetes (Wald chi-squared test, P < 0.001; P for linearity = 0.005) independent of demographic variables, family history of diabetes, BMI and fasting glucose; therefore, we used Youden's J statistic to dichotomize alanine aminotransferase [threshold ≥ 0.43 μkat/L ( ≥ 26 IU/l)

SUBMITTER: Lorenzo C 

PROVIDER: S-EPMC5075526 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature