The role of anisotropic expansion for pulmonary acinar aerosol deposition.

ABSTRACT: Lung deformations at the local pulmonary acinar scale are intrinsically anisotropic. Despite progress in imaging modalities, the true heterogeneous nature of acinar expansion during breathing remains controversial, where our understanding of inhaled aerosol deposition still widely emanates from studies under self-similar, isotropic wall motions. Building on recent 3D models of multi-generation acinar networks, we explore in numerical simulations how different hypothesized scenarios of anisotropic expansion influence deposition outcomes of inhaled aerosols in the acinar depths. While the broader range of particles acknowledged to reach the acinar region (d_p=0.005-5.0μm) are largely unaffected by the details of anisotropic expansion under tidal breathing, our results suggest never

SUBMITTER: Hofemeier P 

PROVIDER: S-EPMC5075582 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature