A network property necessary for concentration robustness.

ABSTRACT: Maintenance of functionality of complex cellular networks and entire organisms exposed to environmental perturbations often depends on concentration robustness of the underlying components. Yet, the reasons and consequences of concentration robustness in large-scale cellular networks remain largely unknown. Here, we derive a necessary condition for concentration robustness based only on the structure of networks endowed with mass action kinetics. The structural condition can be used to design targeted experiments to study concentration robustness. We show that metabolites satisfying the necessary condition are present in metabolic networks from diverse species, suggesting prevalence of this property across kingdoms of life. We also demonstrate that our predictions about concentration robus

SUBMITTER: Eloundou-Mbebi JM 

PROVIDER: S-EPMC5075777 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature