M-DNA/Transition Metal Dichalcogenide Hybrid Structure-based Bio-FET sensor with Ultra-high Sensitivity.

ABSTRACT: Here, we report a high performance biosensor based on (i) a Cu²⁺-DNA/MoS₂ hybrid structure and (ii) a field effect transistor, which we refer to as a bio-FET, presenting a high sensitivity of 1.7 × 10³ A/A. This high sensitivity was achieved by using a DNA nanostructure with copper ions (Cu²⁺) that induced a positive polarity in the DNA (receptor). This strategy improved the detecting ability for doxorubicin-like molecules (target) that have a negative polarity. Very short distance between the biomolecules and the sensor surface was obtained without using a dielectric layer, contributing to the high sensitivity. We first investigated the effect of doxorubicin on DNA/MoS₂ and Cu²⁺-DNA/MoS₂ nanostructures using Rama

SUBMITTER: Park HY 

PROVIDER: S-EPMC5075907 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature