Multifunctional Cu_2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453.

ABSTRACT: Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu_2-XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.

SUBMITTER: Poulose AC 

PROVIDER: S-EPMC5075932 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature