Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence.

ABSTRACT:

Importance

Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure.

Objective

To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia.

Design, setting, and participants

Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Chi

SUBMITTER: French L 

PROVIDER: S-EPMC5075969 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature