Adiposity and ischemic and hemorrhagic stroke: Prospective study in women and meta-analysis.

ABSTRACT:

Objective

To compare associations of body mass index (BMI) with ischemic stroke and hemorrhagic stroke risk, and to review the worldwide evidence.

Methods

We recruited 1.3 million previously stroke-free UK women between 1996 and 2001 (mean age 57 years [SD 5]) and followed them by record linkage for hospital admissions and deaths. We used Cox regression to estimate adjusted relative risks for ischemic and hemorrhagic (intracerebral or subarachnoid hemorrhage) stroke in relation to BMI. We conducted a meta-analysis of published findings from prospective studies on these associations.

Results

During an average follow-up of 11.7 years, there were 20,549 first strokes, of which 9,993 were specified as ischemic and 5,852 as hemorrhagic. Increased BMI was associated with an

SUBMITTER: Kroll ME 

PROVIDER: S-EPMC5075975 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature